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Specific 20S proteasome subunits have been shown to acquire post-translational modifications like glutathionylation, carbonylation, glycoxidation and lipoxidation upon oxidative stress, impairing the proteasome activity (Lefaki et al, 2017b)

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The lower levels of GSH can be attributed to various factors, such as a lack of LC in the diet, increased production of ROS and oxidative stress caused by the consumption of an energy-rich diet, and/or increased utilization of GSH compared to its biosynthesis

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