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Semaglutide slows gastric emptying by 2030%, potentially reducing absorption of oral antibiotics

Moreover, after systemic administration, PROTACs may undergo substantial dilution and loss of effective exposure before reaching target cells due to circulation, tissue distribution, protein binding, metabolic clearance, and nonspecific uptake [4], further underscoring the need for efficient delivery systems

Gradual dose escalation and dietary modifications can help minimise these symptoms during the adjustment period

Aim for lean protein sources (chicken, fish, beans, lentils) and high-fiber foods (fruits, vegetables, whole grains) at every meal