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Front Endocrinol 6(9):657 Dai H, Kustigian L, Carney D, Case A, Considine T, Hubbard BP, Perni RB, Riera TV, Szczepankiewicz B, Vlasuk GP, Stein RL (2010) SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator