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Chronic uninterrupted use beyond 4 weeks lacks safety data

A randomized, double-blind, placebo-controlled trial in 153 older adults taking the antidepressant citalopram found daily supplementation with 500 g vitamin B 12 , 2 mg of folic acid, and 25 mg of vitamin B6 for one year did not reduce the severity of depressive symptoms but increased the response to drug treatment and helped to prevent symptom relapse (112), suggesting B-vitamin supplementation might provide some benefit as an adjunct therapy

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The peptide has been studied in multiple wound types including incisional/excisional wounds, deep burns, diabetic ulcers, and alkali burns in animal research