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GLP-1 stimulation in the microbiome Human intestinal cells show Akkermansias effect on GLP-1 production Akkermansia secretes p9 protein which stimulates GLP-1 production Clostridium butyricum increases GLP-1* Dose-dependent increase of GLP-1 by Clostridium butyricum in a cell-based assay *Based on internal Pendulum R&D data Breakthrough clinical research Were continually pushing the boundaries in scientific research, and were excited to conduct a human clinical trial on GLP-1 and the gut microbiome

Matched patients included 279,064 patients on GLP-1 drugs and 279,064 on a DPP-4 inhibitor

Pregnant and breastfeeding patients should avoid BPC-157 until human safety data is available

Boulware SD, Tamborlane WV, Rennert NJ, Gesundheit N, Sherwin RS