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A list of candidate biomarkers was determined from the proteins that presented a Welch t-test q- value less than 0.05 (after BenjaminiHochberg correction for multiple testing) and from the top contributors in component 1 and 2 of a sparse partial least square discriminant analysis (sPLS-Da) computed with the Mixomics R package 56

These approaches include antioxidant supplementation, dietary patterns, and lifestyle interventions

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The pathogenesis of each autoimmune disease and the therapeutic targets of beneficial intestinal Clostridium are illustrated in Table 2