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Despite the sample size being low ( N = 32) and these results may be attributed to differences in their dietary patterns, the authors observed that these microbial changes appear to contribute to the pathogenesis of BD

deSUMOylation of human RanGAP1-SUMO1 To demonstrate the ability of SnCE1 to cleave SUMO directly from protein substrates and not only poly-SUMO conjugates, 48 nM Hs RanGAP1-SUMO1 was incubated with 144 nM wild type SnCE1 or the inactive mutant SnCE1 C256A at room temperature as described before 110

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The pancreatic-endocrine-osseous axis involves a potential link between DPP-4, bone, and energy metabolism through the receptor activator of nuclear factor kappa B ligand (RANKL), which induces DPP-4 expression in osteoclasts, leading to decreased GLP-1 levels and increased blood glucose levels