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Why Lipase Outperforms Amylase Higher sensitivity for acute pancreatitis Greater specificity for pancreatic pathology Remains elevated longer, providing a wider diagnostic window Less affected by non-pancreatic conditions Better correlation with pancreatic injury The Challenge with Amylase Can be elevated in salivary gland disease, renal impairment, gastrointestinal disorders, and macroamylasemia May normalize early, leading to missed diagnoses Lower specificity for pancreatic disease Limited value when used alone in modern pancreatitis workups In an era where laboratory medicine is increasingly evidence-driven, the question is no longer: "Can we measure amylase?" The real question is: "Does measuring amylase add meaningful clinical value when lipase is available?" As laboratory professionals, our responsibility extends beyond generating results, we must ensure that every test ordered contributes to accurate diagnosis, improved patient outcomes, and optimal resource utilization

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