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The only long-term trial was discontinued due to a case of fatal myocardial infarction, deemed unrelated to CJC-1295 itself [9]

The glucagon receptor arm the feature that distinguishes retatrutide from earlier-generation incretin compounds drives hepatic glucose metabolism, lipid oxidation, and energy expenditure effects, all absent from GLP-1 mono-agonists and dual GLP-1/GIP agonists

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