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It stimulates certain MMPs necessary for the physiological remodeling of damaged tissue, while inhibiting the overactivation of MMPs that contributes to chronic dermal matrix degradation observed in photoaging
Indeed, there may be synergy between FGF-21 and GCG receptor agonism, due to their similar metabolic actions, particularly related to brown adipose tissue differentiation and activation [32], with FGF21 having additional actions in the liver, reducing hepatic lipogenesis and enhancing hepatic insulin sensitivity [66, 67]
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