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The mean P app value for CNS compounds such as dextromethorphan, caffeine, flumazenil, raclopride, buprenorphine, befloxatone, and propranolol, was about 30.1 4 10 6 cm.s 1 (range: 21.7 10 6 cm.s 1 to 38.4 10 6 cm.s 1 ) consistent with high permeability (Fig

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