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IDPs/IDRs exhibit a wide variety of ways of interacting with other molecules, resulting in many unconventional complexes (Uversky, 2011)

The primary analysis of SMR change from baseline was based on a linear mixed model with treatment and stratification factors (site and gender) as class effects, SMR at baseline and change in body weight as covariates, subject as random effect and study day as a repeating factor

Previously approved diabetes drugs were weight neutral or caused weight gain, a concern because obesity is often a co-morbidity of T2DM and can increase the risk for a cardiovascular complication, such as a heart attack or stroke