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It is often described as a stroke of the optic nerve, though the pathophysiology is more specific: NAION occurs when blood flow to the anterior portion of the optic nerve head becomes insufficient, leading to ischemic injury

Other factors that may contribute include sleep disruption, stress related to lifestyle changes, or pre-existing mood conditions that become more apparent during treatment

Understanding the distinct mechanisms and indications of each treatment is essential when considering their use together, particularly as Mounjaro's effects on appetite and food intake may impact overall nutritional status