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Muscle is not cosmetic it is metabolically active tissue that: Regulates glucose disposal Maintains resting metabolic rate Protects long-term weight stability When muscle mass drops, metabolism slows setting the stage for rebound weight gain

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*Eligible patients with a BMI of 30, or 27 with weight-related comorbidities, lost an average of 8% of their body weight (-18.5 lbs) in a 56-week clinical trial evaluating 3.0 mg liraglutide, when combined with a reduced-calorie diet and increased physical activity

This disruption promotes enhanced diffusion of the encapsulated drug across the skin barrier [313, 314]