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The expression of GPX3 can inhibit the activation of NF-B through the Erk pathway, leading to the suppression of the cell cycle proteins B1 and G2/M and the inhibition of epithelial-mesenchymal transition (EMT) by downregulating the Erk-NF- B-SIP 1 signaling axis (40)

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Other serious side effects may include pancreatitis, changes in vision, low blood sugar when combined with insulin or sulfonylureas, dehydration leading to kidney problems, severe gastrointestinal symptoms, gallbladder issues, and serious allergic reactions