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By breaking down intracellular components, autophagy sustains bioenergetic balance and promotes cell survival until favorable conditions are restored ( Autophagy is a highly conserved catabolic process involving four key steps: initiation, autophagosome formation and maturation, fusion with lysosomes, and degradation of autophagic cargo

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To identify potential PAR2-activating proteases expressed in the gut, we performed single-cell RNA sequencing of intestinal crypt cells and identified subpopulations by distinct marker transcripts (Figure 1A and Supplemental Figure 1A

Calculation Glutathione concentration was calculated in mmol/g protein unit