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First, water-soluble hydropersulfides may reduce initiator radicals formed within the aqueous phasefor example, thiyl radicals (GS), which are known to initiate LPO 29,40

Unlike direct GPX4 inhibition, which remains difficult to deploy in vivo owing to bioavailability and systemic toxicity concerns, targeting enzymes that sustain the reduced CoQ 10 (CoQ 10 H 2 , ubiquinol) pool may provide a more tractable and context-selective strategy to lower the ferroptotic threshold in tumors