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This reduction was associated with downregulated NFB expression and partial suppression of MAPK and AP-1 signaling, elucidating that GAC1 may have potential for treating TNF- mediated inflammation [110]

In some embodiments, administration of a formulation or composition or device described herein, in conjunction with otic surgery, medical device implantation, and/or cell transplantation, reduces or prevents cell damage and/or death (e.g., auris sensory hair cell death and/or damage) associated with otic surgery, medical device implantation, and/or cell transplantation

doi: 10.1038/s41467-018-06826-6 33 De MeytsP

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