Canonical GLP-1RAs, such as liraglutide, semaglutide, and tirzepatide (which possesses dual GLP-1/GIP receptor agonist activity), have consistently demonstrated superior metabolic and cardiorenal outcome benefits in large-scale randomized controlled trials (RCTs) ( Regarding weight reduction, pooled results from clinical trials indicate that, compared to placebo, liraglutide at 3.0 mg/d achieves a placebo-subtracted weight loss of approximately 5%
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