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First synthesized in the 1980s at the University of Arizona during research on UVindependent pigmentation, Melanotan II peptide is supplied as a highpurity (9899% by HPLC) lyophilized powder for laboratory research applications

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In particular, in comparison with those who have a low proportion of MMA (III + V) in urine, those who have a higher proportion have been observed to be at higher risks for heart disease, atherosclerosis, peripheral vascular disease, hypertension, and bladder, lung, and skin cancer (reviewed in Steinmaus et al