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GLP-1 agonists are medicines that work like the GLP-1 hormone produced in your body, helping to regulate blood sugar levels in several ways, including: Slowing digestion after a meal (some of these medications more than others) Reducing glucagon from the pancreas (which signals your cells to release stored glucose and increase blood glucose levels) Increasing insulin release from the pancreas Promoting the feeling of being full after eating These medicines help people with type 2 diabetes manage their blood sugar levels

10.1016/j.addr.2007.11.010

Some patients respond better to oral semaglutide than injected, or vice versa, due to absorption differences and individual GI tolerance