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These include muscle weakness (difficulty climbing stairs, rising from a chair, or lifting objects), persistent muscle pain or tenderness, visible muscle swelling or changes in muscle appearance, or dark-colored urine, which may indicate rhabdomyolysisa rare but serious condition involving muscle breakdown

However, they found that in knock-in mice expressing MOR mutant S375A substitution, proposed by these authors to be the primary site of morphine-induced phosphorylation of MOR responsible for desensitization (Schulz et al., 2004), morphine tolerance was not affected (Grecksch et al., 2011)

To become a "blockbuster," it must meet efficacy (big mean body weight loss), tolerability (fewer side effects), and something unique, such as dosing convenience (oral delivery and once-a-month shot)

Photosensitivity is not listed among known adverse effects in UK product information or MHRA guidance