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Ipamorelin produced a selective and dose-dependent increase in GH levels with no significant stimulation of ACTH or cortisol, suggesting hypothalamic specificity. Kraemer et al., Journal of Clinical Endocrinology & Metabolism 2

Schematic representation of the relationship between tyramine dose exposure and the severity of clinical responses, particularly in individuals with impaired tyramine metabolism such as those receiving monoamine oxidase inhibitor (MAOI) therapy