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Eryptosis is characterized by the exposure of PS on the membranes of RBCs, facilitating their clearance from circulation and contributing to anemia in both treated and untreated LC patients

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While glutathione itself crosses this barrier poorly, the brain can synthesize glutathione from precursor amino acids, and systemic glutathione elevation may indirectly support brain glutathione status through various mechanisms including reduced oxidative stress on blood-brain barrier integrity and improved availability of glutathione precursors