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Science 257: 14961502 JessopCE,BulleidNJ (2004) Glutathione directly reduces an oxidoreductase in the endoplasmic reticulum of mammalian cells

Endothelial destruction was patchy at 1 hour with perivascular and intraluminal margination of polymorphonuclear cells and eosinophils

Non-native disulfide bonds are often formed between incorrect cysteine residues, and thus the cell has dedicated a family of oxidoreductases that are thought to isomerize non-native bonds

The research conversation around GHK-Cu has included reports of effects on tissue repair, on collagen and extracellular matrix gene expression, on antioxidant gene networks, on hair follicle biology, and on broader gene expression patterns characterized in transcriptomic studies