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Dietary counseling should focus on high-protein intake (6080 g daily), adequate hydration, vitamin and mineral supplementation adherence, and avoidance of high-calorie liquids and grazing behaviors

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However, the ghrelin receptor couples to multiple intracellular signaling pathways (Gq/11, Gs, beta-arrestin), and different agonists can preferentially activate different pathways a concept termed biased agonism or functional selectivity