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To minimize TMAO production, it is vital to adhere to the divided dosing strategy, keeping single doses under 1,000 mg to ensure maximum small intestinal absorption and minimal spillover into the large intestine

This also raises the question whether PARP activity in BRCA1/2-deficient tumors produces a similar metabolic phenotype via NAD + depletion and whether the use of a PARP inhibitor (e.g., olaparib) to treat these tumors 10 might restore NAD + levels and counterbalance GAPDH inhibition by other oxidative agents

PLOS Biol 19:e3001425 Mu J, Xu J, Zhang L et al (2020) SARS-CoV-2-encoded nucleocapsid protein acts as a viral suppressor of RNA interference in cells

Zhang JH, Hanesworth JM, Sardinia MF, Alt JA, Wright JW, Harding JW