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You may also notice additional symptoms, such as: fever chills pain in your back frequent urination blood-tinged urine nausea or vomiting pain or burning while urinating cramping or pressure in the lower abdomen the urge to urinate even with an empty bladder More on this: UTI symptoms, causes, and treatment Urine color, smell, or consistency changes can also suggest medical conditions like: diabetes liver failure kidney infections bladder infections metabolic disorders For example, frequent foamy urine and leg swelling may indicate kidney disease

Benign familial hypermobility syndrome and Trendelenburg sign in a painting "the three graces" by Peter Paul Rubens (1577-1640)

for example it is the major route of propofol metabolism (Le Guellec et ah, 1995)