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PMID 17074073

Another study that examined the comparative protective effects of conventional and colon-targeted lycopene on acetic acid-induced UC revealed that UC colonic damage, such as ulceration and hemorrhage, was significantly improved in the colon-targeted lycopene group compared with the acetic acid-induced UC group, while no significant changes were observed in conventional lycopene, although there were signs of improvement (Tekeli et al., 2019)

In addition, a meta-analysis suggests it is not the most effective mucolytic agent for COPD (45)

If you are losing weight consistently and tolerating your current dose well, your provider may recommend staying at that dose rather than continuing to increase the dose