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& Angelini, C

451 In streptozotocin (STZ)-induced diabetic rat and mouse models, elevated expression of P2X2 and P2X3 receptors in the DRG, along with increased current density and P2X4 receptor expression on satellite glial cells, indicates that P2X4 receptor activation in the DRG significantly contributes to DPN-induced mechanical pain hypersensitivity (Fig

GHK-Cu (copper peptide) is a lab-tested copper(II)-binding tripeptide (3 amino acids, copper complex)

The discovery that GHK-Cu binds directly to SIRT1 (Li et al., 2025) has generated particular interest, as SIRT1 is a central regulator of cellular longevity and stress resistance