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Quantification was performed at the fragment level with channel interference removal enabled, a 1% false discovery rate was used for protein, peptide and peptide spectral match level identification, inbuilt normalisation was applied with a minimum three fragment ions used for quantification

Human trials remain scarce

half-maximal effective concentration (EC 50 ) values (mean s.d.) of iFSP1 ( 1 ) and its derivatives ( 2 14 ) calculated from experiments performed at least twice in triplicate are shown in the table with the corresponding chemical structures depicted below

50 Once symptoms develop or become inevitable, dialysis or a kidney transplant is necessary