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Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation

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Ngal (Neutrophil gelatinase-associated lipocalin) is an early predictor of acute kidney injury after cardiac surgery and variation of ngal values in homogenous study subject

In mechanistic studies, the combination is explored for its effects on downstream second messenger profiles, including cAMP linked signalling, calcium flux dynamics, and MAPK ERK pathway activation, alongside receptor internalisation and desensitisation kinetics