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Not only that, HA-DEX-DOX nanoparticles composed of micelles containing the chemotherapeutic drug doxorubicin, selenium nanoparticles (SeNPs) and CS-I/J@CM NPs nanoparticles composed of Cu2-xSe, indoxime (IND, an inhibitor of indolamine-2,3-dioxygenase in tumors), JQ1 (PD-L1 inhibitor) and tumor cell membranes can all repolarize M2 macrophages into M1 macrophages thereby exerting immunomodulatory effects to inhibit tumor growth (6466)