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As description indicates in previous work, under conditions with high levels of reactive oxygen molecules, estrogens undergo processing by specific enzymes such as CYP1B1 into forms called 4-hydroxyestrogens that show high reactivity, and these then undergo further oxygen reactions into molecules called quinones

Clinical use shows HbA1c reductions often exceeding 1 percent from baseline, and these agents are recommended for patients not meeting glycemic targets with first-line therapy

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