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Nevertheless, in the context of pathological stimuli such as hypoxia, microbial infection, or tumorigenesis, the levels of exRNA demonstrate a dosedependent increase, attaining concentrations 10to 100fold higher than the baseline [126]

The prepared slides were examined under light microscopy (Olympus, Japan) at 4- 40X [30]

However, in IH LATE , where IH is experienced after the first critical period and during the final stages of neurogenesis, the neuronal proportions generated by HIF1a +/- and wildtype NSCs were similar to one another (Supplemental Figure S3C)