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The effect of Tempo and MitoTEMPO on oocyte maturation and subsequent embryo development in bovine model

Studies have shown that ROS is involved in necroptosis, particularly mitochondrial ROS, which promotes the autophosphorylation of RIP1 necessary for the inscription of RIP3 into necrosomes, and also ROS, which is dependent on RIP3, promotes necroptosis [64]

This work was supported by the National Natural Science Foundation of China (82370069, 82305214), the Natural Science Foundation of Hunan Province (2025JJ60771, 2023JJ40401), the open Fund for the Cultivation Base of the State Key Laboratory of Traditional Chinese Medicine Powder and Innovative Medicine Research in Hunan Province (2024PTKF1007), the Key Research and Development Program of Ningxia Autonomous Region (2023BEG02033) and the undergraduate Research and Innovation Fund of Hunan University of Traditional Chinese Medicine (2025BKS146)

Physicochemical principles that regulate the competition between functional and dysfunctional association of proteins