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These adaptations are mediated by increased mitochondrial biogenesis, enhanced insulin sensitivity, stimulation of anabolic pathways, and the release of myokines such as irisin, apelin, and IL-6, which promote muscle remodeling and systemic metabolic improvements (32)

However, mating WT female mice with 1-year-old GPX5 KO male mice found a higher incidence of offspring miscarriage and developmental malformations, which are related to oxidative stress damage in sperm (Chabory et al., 2009)