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Mutations in these genes not only cause severe obesity but also frequently lead to a broad spectrum of neurological phenotypes, including intellectual disability, developmental delay, and behavioral abnormalities (e.g., autism-like features), highlighting the foundational role of hypothalamic development in energy homeostasis [12,14]

This has led to serious side effects, including nausea, vomiting, abdominal pain, fainting, headaches, dehydration, pancreatitis, and gallstones

3 COMT inhibitors, such as entacapone, opicapone, and tolcapone, and MAO-B inhibitors, such as selegiline, rasagiline, and safinamide, work by enhancing levodopas duration of action with inhibition of their respective enzymes

Full-fat dairy products (whole milk, cream, cheese, ice cream) are particularly challenging during GLP-1 therapy because lipids slow gastric emptying further