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Another relevant limitation is that the severity of symptoms was not incorporated into the analysis, which may influence the observed efficacy of antioxidant therapies, particularly in cases with more severe clinical presentations

Aspirin-Induced Blood Loss Can Deplete Iron The authors of a 2018 literature review call aspirin-induced gastric mucosal damage, gastric ulcers, and increased gastrointestinal bleeding risk well established. Researchers citing reports that aspirin causes gastrointestinal blood loss investigated potential depletion of iron which is often lost with blood

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