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Methods Experimental animals Three strains of male rats were included in this study: Sprague-Dawley (SD) rats, Wistar Kyoto (WKY) rats, and Spontaneously Hypertensive (SHR) rats

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These key enzymes in these pathways are GPT, GOT, and phosphoserine aminotransferase 1 (PSAT1)each of which produces a different amino acid by-product in addition to -KG

The molecules bind to some receptors, but not enough to trigger the cascade of effects that produce appetite suppression, improved insulin sensitivity, and the metabolic changes that drive weight loss