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Saxton, R

Activating GPX4 can significantly reduce ferroptosis in intestinal epithelial cells (IECs) and improve IBD symptoms ( The role of ferroptosis in the pathogenesis of IBD involves multiple pathways, including iron metabolism disorders, intestinal epithelial barrier damage, genetic susceptibility, immune dysregulation, and gut microbiota imbalance

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Jackson Laboratories) were fed a diabetogenic diet, which is high-fat diet with 60% kcal from fat (high-fat diet (60%) diet D12492