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Clinical trial results by dose level The SURMOUNT-1 trial, published in the New England Journal of Medicine, evaluated tirzepatide for weight management in adults with obesity

Human data remain limited, and most studies are small, single-center, or use copper peptide formulations combined with other ingredients (which makes it hard to isolate GHK-Cu's specific contribution): A 2016 Lee et al

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Prior art literature such as United States Patents US4797284 and US4880633 had employed propylene glycol as a penetration enhancer which is gelled with 2 percent hydroxypropyl guar (HP-60 Jaguar from Celanese) which served as a dissolved drug reservoir