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Its Phase 2 obesity trial published in Lancet Diabetes & Endocrinology (2024) showed up to 18.7% weight loss at 46 weeks, while a separate Phase 2 MASH trial demonstrated significant MASH resolution, earning FDA Breakthrough Therapy Designation

In the absence of sufficient glutathione buffering, oxidative damage accumulates in pancreatic -cells, hepatocytes, adipocytes, and vascular tissues

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Mitochondrial function and energy demand: When energy demand increases (such as during exercise or in a low-temperature environment), L-carnitine reduces reliance on glycolysis by enhancing the rate of fatty acid oxidation