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Since mouse microbiome profiles often highly correlate with body weight and fat composition, this study was designed to test whether the cecal microbiomes of DIO mice treated with NNMTi and LD were comparable to the microbiomes of age-matched lean counterparts and distinct from microbiomes of DIO mice maintained on a high-fat Western diet (WD) or subjected to LD switch alone

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They modulate the Nrf2 pathway, stimulate the production of antioxidant enzymes, and protect against OS

Morgan analysts told CNBC that the results were disappointing, but they see potential for amylin analog drug groups for obesity treatment