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Abstract The anorexigenic peptide glucagon-like peptide-1 (GLP-1) is secreted from gut enteroendocrine cells and brain preproglucagon (PPG) neurons, which respectively define the peripheral and central GLP-1 systems

Future research should focus on personalized strategies, utilizing microbiome features, blood metabolites, and customized dietary interventions to enhance the effectiveness of these therapies

During oxidative stress, Nrf2 translocates into the nucleus to regulate the transcription and expression of antioxidant response elements (ARE), activating the intracellular antioxidant enzyme system to eliminate excess ROS and bolster the cells antioxidant capacity ( The inflammatory response is intricately linked to redox balance, with ROS serving as key pro-inflammatory mediators

Each dot represents one sgRNA, n = 10 for each gene