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Understanding the contribution of lifestyle in breast cancer risk prediction: a systematic review of models applicable to Europe

Therefore, the reduction in its effect observed by year five likely reflects the cessation of therapy rather than the development of pharmacologic tolerance or adaptation

McGrail DJ, Garnett J, Yin J, Dai H, Shih DJH, Lam TNA, Li Y, Sun C, Li Y, Schmandt R, Wu JY, Hu L, Liang Y, Peng G, Jonasch E, Menter D, Yates MS, Kopetz S , Lu KH, Broaddus R, Mills GB, Sahni N, Lin SY

The freeze-thaw cycle can damage the delicate peptide structure, a process called denaturation, which can reduce its effectiveness