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Important safety considerations include risk of pancreatitis (treatment should be discontinued if suspected), gallbladder disease, and potential worsening of diabetic retinopathy in patients with pre-existing retinopathy who experience rapid improvement in glucose control (particularly with semaglutide)

40 Glutathione absorption by the orobuccal route is thus a highly prized tool in the armamentarium of the practitioner, but one that is poorly understood and its reliability for long-term drug delivery, eg that of glutathione, needs investigation

[1] [5] According to FDA prescribing information, serious hypersensitivity reactions, including anaphylaxis and angioedema, have been reported in patients treated with tirzepatide