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WADA 2026 list International Council for Harmonisation

Histamine can be stimulating or inhibiting in its actions, affecting multiple regions of the brain as well as the skin, cardiovascular, digestive, respiratory, reproductive, and immune systems.[3] Common causes for histamine intolerance include: Inflammatory bowel diseases (or anything that causes damage to the enterocytes the cells that line the gut) Coeliac disease Intestinal dysbiosis Small Intestinal Bacterial Overgrowth (SIBO) Parasitic infections, like Giardia Leaky gut or increase in intestinal permeability Alcohol or other DAO inhibitors Excess biogenic amines in diet Medications that increase histamine Food allergies Genetic polymorphisms, like MTHFR and others that lower DAO, MAO, ALDH Vitamin cofactor deficiencies enzymes, like DAO and MAO rely on vitamin co-factors and deficiencies of these can also cause abnormal enzyme activity The primary pathway by which endogenous histamine is metabolised in the body is via the enzyme histamine methyltransferase (HMT)

This underscores the importance of holistic weight management approaches, considering long-term health and behavioral factors

doi: 10.1056/NEJMe2202547 123 IottiS.WolfF.MazurA.MaierJ