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Oral administration increased plasma GLP-1 levels compared with water during an intraperitoneal glucose tolerance test, and ileal administration reduced plasma DPP4 activity and increased the ratio of active GLP-1 to total GLP-1 (Reference Ishikawa, Hira and Inoue69) in rats

The researchers also noted that 23.5% (95% CI, 22.3-24.8) of people meeting FDA indications for tirzepatide reported using medications that may slow gastrointestinal motility, which could increase gastrointestinal adverse effects when combined with any GLP-1 receptor agonist