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A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

Compared with differentiated tumor cells, CSCs rely heavily on lipid metabolism to maintain their stemness and fulfill intracellular biosynthesis and energy metabolism requirements (89)

This fundamental understanding has directly catalyzed a paradigm shift in therapeutic development, moving from widespread insulin replacement to targeted interventions aimed at addressing the root causes of the disease

Monoacylglycerol lipase: a novel potential therapeutic target and prognostic indicator for hepatocellular carcinoma